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Scientist/Sr. Scientist - Protein Engineering

Company: Medix---
Location: Hayward
Posted on: May 17, 2022

Job Description:

Job Summary:
We are looking for a protein biochemist/molecular engineer to join our Platform Technology group. This individual will work closely with our Scientists to engineer CRISPR ribonucleoprotein (RNP) complexes for direct/cell-targeted in vivo delivery, for therapeutic genome editing. The successful candidate will have extensive, hands-on experience with rational engineering and/or screening-based approaches to optimize protein activity, a passion for working on new and highly differentiated early-stage prototypes, and a clear record of being able to move projects forward.
Primary Responsibilities:
Lead protein engineering efforts to optimize TAGE cell-specificity, trafficking, and stability
Perform mechanistic characterization of TAGE activity and stability
Perform ex vivo and in-vivo characterization of TAGE activity, quantify DNA repair outcomes from gene editing experiments
Coordinate efforts with internal and external stakeholders
Communicate results clearly and concisely, keep accurate record of experiments and results
Doctoral degree (PhD or equivalent) in a related scientific discipline
Experience with rational or screen-based engineering to optimize protein activity
Experience with cell-based assays
Track record of moving projects forward
Experience with CRISPR-Cas and/or Antibody engineering, expression, purification, and characterization
Experience with chemical and/or bioconjugation methods and related analytical techniques
Experience in a variety of chromatography techniques including affinity, IEX, SEC and familiarity with writing methods for the -'KTA FPLC
Experience or a high level of familiarity with NGS-based analytical techniques
Experience or a high level of familiarity with genome editing
Experience or a high level of familiarity with biologic delivery and/or endolysosomal trafficking
Experience inspiring and leading a small team

We are committed to creating a diverse environment and are proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, disability, age, or veteran status.

Keywords: Medix---, Hayward , Scientist/Sr. Scientist - Protein Engineering, Engineering , Hayward, California

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