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Principal Investigator/Research Fellow/Director - DMPK

Company: Arcus Biosciences, Inc.
Location: Hayward
Posted on: May 12, 2022

Job Description:

Principal Investigator/Research Fellow/Director - DMPK Arcus Biosciences is seeking a highly motivated and experienced individual to join our Drug Metabolism and Pharmacokinetics (DMPK) Department. The successful applicant will be a key member of our multi-disciplinary project teams and will be responsible for leading effective DMPK support to the discovery and development of novel immunotherapy drug candidates. Title will be commensurate with experience. Core responsibilities:

  • Develop DMPK strategy and drive its execution in support of Discovery and Clinical Development milestones
  • Represent DMPK in Discovery and Development project teams
    • Identify and address critical ADME-centric issues
    • Provide guidance to Medicinal Chemistry on lead optimization
    • Collaborate with Biology and Translational Sciences to define PK/PD relationships
    • Select and characterize clinical development candidates with appropriate ADME properties
    • Oversee DMPK studies in support of clinical development
    • Author and review nonclinical PK sections and study reports for regulatory submissions
    • Manage and/or mentor scientists and research associates Qualifications:
      • Ph.D. degree in pharmacokinetics, pharmaceutical sciences, or related discipline with 6+ years of industrial experience
      • In-depth understanding of DMPK principles and demonstrated ability to integrate information, from both literature and internal research, for addressing ADME-related issues
      • Experience supporting the discovery and development of drug candidates as a DMPK representative gained in an appropriate industrial environment
      • Experience in the preparation of regulatory documents and familiarity with DMPK-related regulatory guidance
      • An established track record as a highly collaborative team player who works effectively on cross-functional project teams and builds strong relationships with key stakeholders
      • Strong work ethic and organizational skills
      • Experience managing and mentoring junior scientists and research associates Arcus Biosciences is an equal opportunity employer.

Keywords: Arcus Biosciences, Inc., Hayward , Principal Investigator/Research Fellow/Director - DMPK, Executive , Hayward, California

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