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Bioinformatics Specialist, Platform Technology

Company: Spotlight Therapeutics
Location: Hayward
Posted on: May 9, 2022

Job Description:

Spotlight Therapeutics is aiming to unlock the full potential of CRISPR-based medicines by delivering cell-targeted gene editors in vivo, moving beyond AAV and LNPs. We have developed a proprietary platform to engineer CRISPR-Cas ribonucleoproteins (RNPs) for in vivo delivery to key cell types to treat diseases beyond the liver, beginning with cancer and monogenic diseases.

Job Summary:
We are seeking a highly motivated, passionate, and enthusiastic bioinformatician/computer scientist with a background in genomics and next-generation sequencing (NGS) technology to join our Platform Technology group. This individual will oversee our core gene editing NGS pipeline as well as work with scientists across the organization to manage, analyze, and interpret biological data across a range of experimental workflows. This position is an outstanding opportunity to manage critical analytical infrastructure, help drive the development of our core technology, and to collaborate with our cell biologists, immunologists, protein biochemists, and gene editing experts.

The ideal candidate will have a Bachelor's or Master's degree in quantitative sciences (Computer Science, Mathematics, Bioinformatics, or equivalent) and experience with bioinformatics, programming (bash and python or similar), data analysis, and data management. Domain knowledge in gene editing, DNA repair, and/or CRISPR biology is a plus, but not necessary. However, the candidate must be willing and eager to learn the biology required to leverage their analytical skills within our group.

The ideal candidate would be able to quickly learn new bioinformatic skills and to apply their knowledge of computer science to gene editing, protein engineering, and CRISPR biology. -We encourage all applicants that have a curious mindset, an attention to detail, a drive to find better ways to do things, and a willingness to learn from others in the organization.

Primary Responsibilities:
--- - - - - -Oversee, maintain, and streamline our core next-generation sequencing (NGS) analysis pipeline
--- - - - - -Collaborate with our wet-lab scientists to problem-solve NGS-related issues to ensure data is accurate and reliable
--- - - - - -Train and assist researchers in the use of analysis pipelines
--- - - - - -Work with Scientists and Research Associates to interpret biological data across diverse experimental workflows (ex. RNA-Sequencing) and to spearhead new analytical methods
--- - - - - -Assist in the maintenance of data in Spotlight's lab information system (Benchling), and external data storage backups including AWS and google drive
--- - - - - -Communicate results clearly and concisely, maintain careful records of analysis and results, and clearly document code

--- - - - - -BS/MS in bioinformatics, computer science, or mathematics or a related discipline
--- - - - - -Hands-on experience or at least a high level of familiarity with next-generation sequencing wet-lab sample preparation, workflows, and analytical methods
--- - - - - -A willingness and eagerness to learn domain specific biology and bioinformatic analysis
--- - - - - -Must be highly collaborative, team-oriented, and have excellent written and oral communication skills

--- - - - - -Experience programming in Python or R (or another similar language)
--- - - - - -Basic command line proficiency (Linux and bash scripts)
--- - - - - -Familiarity with cloud computing (especially AWS)
--- - - - - -Familiarity with git version control
--- - - - - -Familiarity with IPython notebooks or Jupyter Notebooks
--- - - - - -Familiarity with lab information management systems (LIMS), especially Benchling
--- - - - - -Experience with wet-lab work in a biology setting

Please include a cover letter (merged with your CV in a single document) in your submission.

At Spotlight Therapeutics, we are committed to creating a diverse environment and are proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, disability, age, or veteran status.

Keywords: Spotlight Therapeutics, Hayward , Bioinformatics Specialist, Platform Technology, IT / Software / Systems , Hayward, California

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