Bioinformatics Specialist, Platform Technology
Company: Spotlight Therapeutics
Location: Hayward
Posted on: May 9, 2022
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Job Description:
Spotlight Therapeutics is aiming to unlock the full potential of
CRISPR-based medicines by delivering cell-targeted gene editors in
vivo, moving beyond AAV and LNPs. We have developed a proprietary
platform to engineer CRISPR-Cas ribonucleoproteins (RNPs) for in
vivo delivery to key cell types to treat diseases beyond the liver,
beginning with cancer and monogenic diseases.
Job Summary:
We are seeking a highly motivated, passionate, and enthusiastic
bioinformatician/computer scientist with a background in genomics
and next-generation sequencing (NGS) technology to join our
Platform Technology group. This individual will oversee our core
gene editing NGS pipeline as well as work with scientists across
the organization to manage, analyze, and interpret biological data
across a range of experimental workflows. This position is an
outstanding opportunity to manage critical analytical
infrastructure, help drive the development of our core technology,
and to collaborate with our cell biologists, immunologists, protein
biochemists, and gene editing experts.
The ideal candidate will have a Bachelor's or Master's degree in
quantitative sciences (Computer Science, Mathematics,
Bioinformatics, or equivalent) and experience with bioinformatics,
programming (bash and python or similar), data analysis, and data
management. Domain knowledge in gene editing, DNA repair, and/or
CRISPR biology is a plus, but not necessary. However, the candidate
must be willing and eager to learn the biology required to leverage
their analytical skills within our group.
The ideal candidate would be able to quickly learn new
bioinformatic skills and to apply their knowledge of computer
science to gene editing, protein engineering, and CRISPR biology.
-We encourage all applicants that have a curious mindset, an
attention to detail, a drive to find better ways to do things, and
a willingness to learn from others in the organization.
Primary Responsibilities:
--- - - - - -Oversee, maintain, and streamline our core
next-generation sequencing (NGS) analysis pipeline
--- - - - - -Collaborate with our wet-lab scientists to
problem-solve NGS-related issues to ensure data is accurate and
reliable
--- - - - - -Train and assist researchers in the use of analysis
pipelines
--- - - - - -Work with Scientists and Research Associates to
interpret biological data across diverse experimental workflows
(ex. RNA-Sequencing) and to spearhead new analytical methods
--- - - - - -Assist in the maintenance of data in Spotlight's lab
information system (Benchling), and external data storage backups
including AWS and google drive
--- - - - - -Communicate results clearly and concisely, maintain
careful records of analysis and results, and clearly document
code
Qualifications:
--- - - - - -BS/MS in bioinformatics, computer science, or
mathematics or a related discipline
--- - - - - -Hands-on experience or at least a high level of
familiarity with next-generation sequencing wet-lab sample
preparation, workflows, and analytical methods
--- - - - - -A willingness and eagerness to learn domain specific
biology and bioinformatic analysis
--- - - - - -Must be highly collaborative, team-oriented, and have
excellent written and oral communication skills
Nice-to-haves:
--- - - - - -Experience programming in Python or R (or another
similar language)
--- - - - - -Basic command line proficiency (Linux and bash
scripts)
--- - - - - -Familiarity with cloud computing (especially AWS)
--- - - - - -Familiarity with git version control
--- - - - - -Familiarity with IPython notebooks or Jupyter
Notebooks
--- - - - - -Familiarity with lab information management systems
(LIMS), especially Benchling
--- - - - - -Experience with wet-lab work in a biology setting
Please include a cover letter (merged with your CV in a single
document) in your submission.
At Spotlight Therapeutics, we are committed to creating a diverse
environment and are proud to be an equal opportunity employer. All
qualified applicants will receive consideration for employment
without regard to race, color, religion, gender, gender identity or
expression, sexual orientation, national origin, genetics,
disability, age, or veteran status.
Keywords: Spotlight Therapeutics, Hayward , Bioinformatics Specialist, Platform Technology, IT / Software / Systems , Hayward, California
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