Principal / Senior Principal Scientist, Computational Chemistry/ Cheminformatics
Company: Genentech
Location: Hayward
Posted on: January 18, 2023
Job Description:
The PositionGenentech seeks a computational chemist with strong
experience in structure-based drug design, ligand-based design,
cheminformatics, and scientific programming to join our
Computational Drug Discovery group within the Discovery Chemistry
Department. - In addition to applying computational chemistry
methods to support drug discovery, optimization, and development
within medicinal chemistry project team settings, you will engage
in scientific programming to enhance our scientific methods and
capabilities. - You will interact closely with interdisciplinary
small molecule discovery project team members and other members of
the Computational Chemistry and Cheminformatics group. - The
position entails approximately 50% application-oriented
computational chemistry and 50% software development/support,
including cheminformatics and computational chemistry tool
development and integration from 3rd parties. -You will have access
to state of the art modeling, simulation, and machine learning
technologies as well as computing infrastructure, and be able to
leverage rich collections of data to accelerate drug discovery in a
fast-paced and creative environment. - Based at our beautiful South
San Francisco campus, you will join our computational chemists,
cheminformaticians, and software engineers who are committed to
discovering new medicines to address unmet medical needs. This is a
tremendous opportunity to do meaningful work in an exciting,
dynamic environment.Who You Are
- Ph.D. or equivalent in Chemistry, Biochemistry, Biophysics, or
other related disciplines.
- 5+ years of Industry experience in small molecule drug
discovery is required.
- Strong experience in structure and ligand-based design, QSAR,
QSPR, conformational analysis, physical chemical property modeling,
molecular mechanics and dynamics, quantum mechanics, statistical
design of experiments, multiparameter optimization, and
A.I./machine learning is needed.
- Excellent interpersonal, verbal and written communication
skills are essential.
- We also require a sophisticated understanding of algorithms and
methods for computational chemistry and cheminformatics/database
applications, along with demonstrated understanding of software
development strategy and practice. -
- A solid understanding of experimental assay methods and
technology used to identify and quantify protein-ligand
interactions, a working knowledge of in vitro/in vivo DMPK
principles, and a strong record of publications and presentations
are necessary.
- Practical, working experience with computational chemistry
software from companies such as Chemical Computing Group,
Dotmatics, Schrodinger, OpenEye, and Gaussian.
- Knowledge of multivariate statistics, machine learning, deep
learning approaches is desirable.Relocation benefits are available
for this positionThe expected salary range for this position based
on the primary location of California is $140,210 and $260,390. -
Actual pay will be determined based on experience, qualifications,
geographic location, and other job-related factors permitted by
law. - A discretionary annual bonus may be available based on
individual and Company performance. - This position also qualifies
for the benefits detailed at the link provided
below.#LI-TS5#Genentech#scientistjob#gREDinformaticsGenentech is an
equal opportunity employer, and we embrace the increasingly diverse
world around us. Genentech prohibits unlawful discrimination based
on race, color, religion, gender, sexual orientation, gender
identity or expression, national origin or ancestry, age,
disability, marital status and veteran status.Genentech requires
all new hires to be fully vaccinated against COVID-19 as of their
start date. This requirement is a condition of employment at
Genentech, and it applies regardless of whether the position is
located at a Genentech campus or is fully remote. - If you are
unable to receive the vaccine due to a disability or serious
medical condition, or because it is prohibited as a result of your
sincerely held religious beliefs, you will have an opportunity to
request a reasonable accommodation.Job Facts JOB FUNCTION
COMPANY/DIVISION Genentech SCHEDULE JOB TYPE Full time
Keywords: Genentech, Hayward , Principal / Senior Principal Scientist, Computational Chemistry/ Cheminformatics, Other , Hayward, California
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