Senior Scientist, Discovery Analytical Sciences
Company: Eikon Therapeutics
Location: Hayward
Posted on: January 21, 2023
Job Description:
Company DescriptionEikon Therapeutics is a new biopharmaceutical
company employing revolutionary technology at the intersection of
chemistry, engineering, computation, and biology to discover novel
treatments for life-threatening diseases. Eikon's discovery
platform is built on groundbreaking innovations from its founders
(Nobel Prize, 2014), culminating in the creation of microscopes
which enable real time, molecular-resolution measurements of
protein movement in living cells, thereby unlocking otherwise
intractable classes of proteins as drug targets.PositionThe
position, joining early at Eikon, will be an essential part of an
interdisciplinary founding team of highly creative and talented
individuals with outstanding expertise to support and advance
Eikon's core platform technologies. The main responsibility is to
own the workflow of high-throughput small-molecule purification to
support drug-discovery. In addition, the position will actively
engage in developing and expanding analytical and purification
workflows useful in the drug-discovery process. About YouYou are an
experienced analytical scientist working in drug-discovery
environment supporting medicinal chemists with purification and
analytical needs. You have solid understanding on the basic
principles of chromatography and the working principles of
chromatographic instruments - both analytical and preparative. If
required, you can troubleshoot a wide array of instrument problems
to reduce downtime. You are curious to identify inefficiencies in
workflow and propose innovative alternatives. You can use a diverse
set of instruments and technologies, such as (but not limited to)
HPLC-MS, SFC-MS, CE, mass-directed purification, preparative
SFC.What You'll Do
- Provide purification and analytical support to the medicinal
chemistry team at Eikon Therapeutics in Hayward, CA.
- Develop chromatographic methods for mass-directed
high-throughput purification of small-molecules
- Ensure that the preparative and the analytical instruments are
maintained in good working condition. Can troubleshoot and perform
minor repairs if required
- Actively participate in research efforts to improve process
efficiencies, expand the range of assays and applications, and
improve technologies and infrastructure - from conceptualizing to
experimental design through implementation
- Anticipate requirement of additional resources, consumables,
and equipment to ensure that work can be completed within a
stipulated time
- May supervise or mentor junior-level staff, participate in
national and international scientific conferences, provide
scientific reports that support generation of publications,
patents, or regulatory submissions
- Make decisions that impact entire work group / project
teamQualifications
- Ph.D. or equivalent advanced degree in analytical sciences with
4+ years of relevant industrial and / or academic experience, or
Master's degree with 14+ years of industrial experience, or
Bachelor's degree with 16+ years of industrial experience
- Experience in purification and analysis of small-molecules by
reversed-phase HPLC and SFC, including fraction collection through
mass-spectrometry-based detection
- Experience of working in high-throughput environment, managing
large numbers of samples and associated data
- Demonstrated problem-solving skills, which includes
troubleshooting processes, instruments, and data management
problems
- Proficiency in computer programming using one or more common or
instrument-specific languages for laboratory automation, and/or
process optimization
- Proficiency in designing and performing experiments, followed
by data compilation and presentation.
- Proficiency in scientific / technical writing including
generation of reports related to publications, patents, or
regulatory submissions
- Excellent communication skills, both oral and written, is
essentialAt Eikon, employee compensation also includes bonus and
equity compensation, in addition to several generous benefit
programs, including:---
- 401k plan with company matching---
- Medical (premiums covered by Eikon at 95%), dental and vision
insurance (premiums covered by Eikon at 100%)---
- Mental health and wellness benefits---
- Weeklong summer and winter holiday shutdowns---
- Generous paid time off and holiday policies---
- Life/AD&D Insurance (premiums covered by Eikon at 100%) and
optional supplemental employee-paid life/AD&D policies ---
- Enhanced parental leave benefit---
- Daily subsidized lunch program when on-site---The expected
salary range for this role is $135,000 to $155,000, depending on
skills, competency and the market demand for your expertise.
Keywords: Eikon Therapeutics, Hayward , Senior Scientist, Discovery Analytical Sciences, Other , Hayward, California
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