Senior Scientist, Discovery Analytical Sciences

Company: Eikon Therapeutics
Location: Hayward
Posted on: January 21, 2023

Job Description:

Company DescriptionEikon Therapeutics is a new biopharmaceutical company employing revolutionary technology at the intersection of chemistry, engineering, computation, and biology to discover novel treatments for life-threatening diseases. Eikon's discovery platform is built on groundbreaking innovations from its founders (Nobel Prize, 2014), culminating in the creation of microscopes which enable real time, molecular-resolution measurements of protein movement in living cells, thereby unlocking otherwise intractable classes of proteins as drug targets.PositionThe position, joining early at Eikon, will be an essential part of an interdisciplinary founding team of highly creative and talented individuals with outstanding expertise to support and advance Eikon's core platform technologies. The main responsibility is to own the workflow of high-throughput small-molecule purification to support drug-discovery. In addition, the position will actively engage in developing and expanding analytical and purification workflows useful in the drug-discovery process. About YouYou are an experienced analytical scientist working in drug-discovery environment supporting medicinal chemists with purification and analytical needs. You have solid understanding on the basic principles of chromatography and the working principles of chromatographic instruments - both analytical and preparative. If required, you can troubleshoot a wide array of instrument problems to reduce downtime. You are curious to identify inefficiencies in workflow and propose innovative alternatives. You can use a diverse set of instruments and technologies, such as (but not limited to) HPLC-MS, SFC-MS, CE, mass-directed purification, preparative SFC.What You'll Do

• Provide purification and analytical support to the medicinal chemistry team at Eikon Therapeutics in Hayward, CA.
• Develop chromatographic methods for mass-directed high-throughput purification of small-molecules
• Ensure that the preparative and the analytical instruments are maintained in good working condition. Can troubleshoot and perform minor repairs if required
• Actively participate in research efforts to improve process efficiencies, expand the range of assays and applications, and improve technologies and infrastructure - from conceptualizing to experimental design through implementation
• Anticipate requirement of additional resources, consumables, and equipment to ensure that work can be completed within a stipulated time
• May supervise or mentor junior-level staff, participate in national and international scientific conferences, provide scientific reports that support generation of publications, patents, or regulatory submissions
• Make decisions that impact entire work group / project teamQualifications
  • Ph.D. or equivalent advanced degree in analytical sciences with 4+ years of relevant industrial and / or academic experience, or Master's degree with 14+ years of industrial experience, or Bachelor's degree with 16+ years of industrial experience
  • Experience in purification and analysis of small-molecules by reversed-phase HPLC and SFC, including fraction collection through mass-spectrometry-based detection
  • Experience of working in high-throughput environment, managing large numbers of samples and associated data
  • Demonstrated problem-solving skills, which includes troubleshooting processes, instruments, and data management problems
  • Proficiency in computer programming using one or more common or instrument-specific languages for laboratory automation, and/or process optimization
  • Proficiency in designing and performing experiments, followed by data compilation and presentation.
  • Proficiency in scientific / technical writing including generation of reports related to publications, patents, or regulatory submissions
  • Excellent communication skills, both oral and written, is essentialAt Eikon, employee compensation also includes bonus and equity compensation, in addition to several generous benefit programs, including:---
    • 401k plan with company matching---
    • Medical (premiums covered by Eikon at 95%), dental and vision insurance (premiums covered by Eikon at 100%)---
    • Mental health and wellness benefits---
    • Weeklong summer and winter holiday shutdowns---
    • Generous paid time off and holiday policies---
    • Life/AD&D Insurance (premiums covered by Eikon at 100%) and optional supplemental employee-paid life/AD&D policies ---
    • Enhanced parental leave benefit---
    • Daily subsidized lunch program when on-site---The expected salary range for this role is $135,000 to $155,000, depending on skills, competency and the market demand for your expertise.

Keywords: Eikon Therapeutics, Hayward , Senior Scientist, Discovery Analytical Sciences, Other , Hayward, California