Director, Biostatistics
Company: Maze Therapeutics
Location: South San Francisco
Posted on: February 4, 2026
|
|
|
Job Description:
The Position As the Director, Biostatistics, you will play an
important role in shaping and supporting the clinical development
of Maze’s therapeutic programs. You will partner closely with
Clinical Science, Regulatory Affairs, Clinical Pharmacology,
Development Science, and Translational Science to ensure our
clinical studies are robust, data-driven, and impactful. In this
role, you’ll oversee biostatistical strategy and execution, from
study design through regulatory submissions, balancing hands-on
expertise with strategic leadership. You will also represent
Biostatistics on clinical study teams, guide interpretation of
complex data, and oversee CRO partners to ensure high-quality
statistical deliverables. The position will report to the Vice
President, Biometrics. The Impact You’ll Have Serve as the
biostatistics lead for clinical studies, providing expert input on
study design, endpoints, and statistical strategy Oversee and
contribute to completion of all technical and operational
statistical activities for a group of clinical trials. Ensure
development and review of statistical analysis plans (SAPs),
including complex and innovative methodologies Collaborate with
cross-functional partners in protocol development, study design
discussions, and data interpretation Partner with Statistical
Programming to generate and validate analyses for internal use,
publications, and regulatory submissions Oversee CRO execution of
statistical tasks: managing timelines, quality, and analytical
approaches Represent biostatistics in regulatory interactions (FDA,
EMA, PMDA, etc.), contributing to briefing documents, meeting
preparation, and responses to agency questions Contribute to
clinical study reports (CSRs), integrated summaries (ISS/ISE), and
regulatory submissions (NDA/BLA/MAA) Apply advanced statistical
techniques to explore, analyze, and interpret clinical, safety,
biomarker, and exploratory data Advise internal and external
partners on statistical approaches, data reliability, model
selection, and interpretation of results Lead the gathering,
organization and analysis of different data sources to enable
delivery of special projects and / or the statistical analysis plan
and clinical study endpoints for assigned products Review and
analyze safety reporting, biomarker analyses and other aspects of
clinical trial monitoring Develop enhancements to statistical
software, as appropriate, by programming new techniques; maintain
knowledge of current and emerging trends in statistical analysis
methodologies and tools Provide biostatistical input into clinical
development documentation, scientific publications and
presentations, and regulatory documentation Adhere to regulatory
requirements of study conduct, statistical analysis principles,
industry standards, and Maze SOPs Support due diligence, licensing,
and partnering activities as needed As a Director, we also expect
you to demonstrate the following Leadership Competencies:
Leadership Competencies Communication and Influence Role models
clear communication and open two-way conversations. Reinforces an
environment where people feel heard and their opinions are valued.
Inspires followership despite differing initial opinions. Teamwork
and Collaboration Champions collaborations and connections across
Maze. Establishes team norms and expectations. Seeks opportunities
to spotlight team and individual contributions in public forums.
Execution and Results Develops recommendations to seize on
opportunities and mitigate obstacles that could impact long-term
success. Coaches others on resource management and work
distribution/delegation. Aligns work to Maze’s strategy, mission,
and vision. Develop Others and Self Develops staff capabilities to
handle delegation of responsibilities. Encourages staff to develop
and execute personal stretch goals. Identifies and recommends ways
to increase inclusive leadership. What We’re Looking For An
advanced degree in Biostatistics, Statistics, or a related field.
Master’s degree with 10 years of experience, or Ph.D. with 8 years
of experience Comfortable being hands-on with analysis,
simulations, and document review Direct experience designing
early-stage trials (Phase I/II) and late-stage trials in
resource-constrained settings Confident decision-maker who can
influence at the executive level Collaborative, mentorship-oriented
leadership style This role follows a hybrid schedule, with an
expectation to be onsite at our South San Francisco headquarters at
least three days per week About Maze Therapeutics Maze Therapeutics
is a clinical-stage biopharmaceutical company harnessing the power
of human genetics to develop novel, small molecule precision
medicines for patients living with renal, cardiovascular and
related metabolic diseases, including obesity. The company is
advancing a pipeline using its Compass platform, which allows it to
identify and characterize genetic variants in disease and then link
those variants to the biological pathways that drive disease in
specific patient groups through a process it refers to as variant
functionalization. The company’s pipeline is led by two wholly
owned lead programs, MZE829 and MZE782, each of which represents a
novel precision medicine-based approach for chronic kidney disease.
Maze is based in South San Francisco. Our People Maze is comprised
of a team of passionate and creative professionals committed to
discovering and delivering transformative medicines to patients
suffering from both rare and common genetic diseases. We are
fostering a culture that encourages vision, initiative and the
development of talent. Our supportive work environment inspires
creative thinking and freedom of expression, resulting in a
stimulating atmosphere where people enjoy coming to work. While we
have a passion for advanced science and pride ourselves on
excellence in execution, ultimately, everything we do is about
patients. Our Core Values Further Together – Our path is paved with
challenges, but with resilience and a team-first mentality, we’ll
achieve our mission. Impact Obsessed – We embrace the bold, take
calculated risks, and learn from our mistakes to improve the lives
of others. Stand True – Our integrity is foundational; it guides us
no matter the obstacle. The expected annual salary range for
employees located in the San Francisco Bay Area is $228,000 –
$280,000. Additionally, this position is eligible for an annual
performance bonus. Maze performs position-based compensation
benchmarking to industry market data to ensure we pay competitive
wages. Determination of starting salary will depend upon a variety
of job-related factors, which may include professional experience,
skills, and job location. The expected salary range for this role
may be modified in the future. Maze offers a robust benefits
package to our eligible employees including competitive medical,
dental, and vision insurance, mental health offerings, equity
incentive plan, 401(k) program with employer match and a generous
holiday and PTO policy. LI-Hybrid
Keywords: Maze Therapeutics, Hayward , Director, Biostatistics, Science, Research & Development , South San Francisco, California
